Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1α
نویسندگان
چکیده
Guillaume PIESSEN*†, Nicolas JONCKHEERE*, Audrey VINCENT*, Brigitte HÉMON*, Marie-Paule DUCOUROUBLE*, Marie-Christine COPIN*‡, Christophe MARIETTE*† and Isabelle VAN SEUNINGEN*1 *Unité INSERM 560, Place de Verdun, 59045 Lille Cedex, France, †Department of Digestive and Oncological Surgery, C. Huriez Hospital, Centre Hospitalier Régional et Universitaire de Lille, 59037 Lille Cedex, France, and ‡Department of Pathology, Parc Eurasanté, CHRU Lille, 59037 Lille Cedex, France
منابع مشابه
Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway.
Abnormal gastro-oesophageal reflux and bile acids have been linked to the presence of Barrett's oesophageal premalignant lesion associated with an increase in mucin-producing goblet cells and MUC4 mucin gene overexpression. However, the molecular mechanisms underlying the regulation of MUC4 by bile acids are unknown. Since total bile is a complex mixture, we undertook to identify which bile aci...
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